Cyclebase 3.0

Cell-cycle regulation database

TYW1 [YPL207W]

S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase; Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron; Belongs to the TYW1 family.

Synonyms:  TYW1,  TYW1p,  Q08960,  Q08960p,  YPL207W ...

Linkouts:  STRING  UniProt