Cyclebase 3.0

Cell-cycle regulation database

PAC1 [YOR269W]

Nuclear distribution protein PAC1; Involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; serves at interface between dynein's ATPase site and its microtubule binding stalk, causing individual dynein motors to remain attached to microtubules for long periods; synthetic lethal with bni1; homolog of human LIS1, mutations in which cause the severe brain disorder lissencephaly

Synonyms:  PAC1,  PAC1p,  P39946,  P39946p,  YOR269W ...

Linkouts:  STRING  UniProt