Cyclebase 3.0

Cell-cycle regulation database

SGT2 [YOR007C]

Small glutamine-rich tetratricopeptide repeat-containing protein 2; Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; similar to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress

Synonyms:  SGT2,  SGT2p,  Q12118,  Q12118p,  UNF346 ...

Linkouts:  STRING  UniProt