Cyclebase 3.0

Cell-cycle regulation database

HMG1 [YML075C]

HMG-CoA reductase; catalyzes conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; one of two isozymes; localizes to nuclear envelope; overproduction induces formation of karmellae; forms foci at nuclear periphery upon DNA replication stress; HMG1 has a paralog, HMG2, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg1 mutant

Synonyms:  HMG1,  HMG1p,  P12683,  P12683p,  YML075C ...

Linkouts:  STRING  UniProt