Cyclebase 3.0

Cell-cycle regulation database

HMG2 [YLR450W]

HMG-CoA reductase; converts HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; one of two isozymes; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks; forms foci at nuclear periphery upon DNA replication stress; HMG2 has a paralog, HMG1, that arose from the whole genome duplication; human homolog HMGCR can complement yeast hmg2 mutant

Synonyms:  HMG2,  HMG2p,  P12684,  L9324.2,  P12684p ...

Linkouts:  STRING  UniProt