Cyclebase 3.0

Cell-cycle regulation database

FPR4 [YLR449W]

Peptidyl-prolyl cis-trans isomerase (PPIase); nuclear proline isomerase; affects expression of multiple genes via its role in nucleosome assembly; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones; PPIase domain acts as a transcriptional repressor when tethered to DNA by lexA, and repressor activity is dependent on PPIase activity; contains a nucleoplasmin-like fold and can form pentamers; Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.

Synonyms:  FPR4,  FPR4p,  Q06205,  L9324.3,  Q06205p ...

Linkouts:  STRING  UniProt