Cyclebase 3.0

Cell-cycle regulation database

DBR1 [YKL149C]

RNA lariat debranching enzyme; catalyzes debranching of lariat introns formed during pre-mRNA splicing; required for efficient Ty1 transposition; knockdown of human homolog Dbr1 rescues toxicity of RNA-binding proteins TDP-43 and FUS which are implicated in amyotrophic lateral sclerosis (ALS), suggests potential therapeutic target for ALS and related TDP-43 proteinopathies; human homolog DBR1 can complement yeast dbr1 null mutant

Synonyms:  DBR1,  DBR1p,  P24309,  P24309p,  PRP26 ...

Linkouts:  STRING  UniProt