Cyclebase 3.0

Cell-cycle regulation database

DPB11 [YJL090C]

DNA replication initiation protein; loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; along with Rfa1p, binds to ultrafine anaphase bridges in mitotic cells and prevents accumulation of chromatin bridges by stimulating the Mec1p kinase and suppressing homologous recombination; ortholog of human TopBP1; forms nuclear foci upon DNA replication stress

Synonyms:  DPB11,  DPB11p,  P47027,  J0918,  P47027p ...

Linkouts:  STRING  UniProt