Cyclebase 3.0

Cell-cycle regulation database

LAG1 [YHL003C]

Longevity assurance gene 1 protein; Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress; homolog of human CERS2, a tumor metastasis suppressor gene whose silencing enhances invasion/metastasis of prostate cancer cells; LAG1 has a paralog, LAC1, that arose from the whole genome duplication

Synonyms:  LAG1,  LAG1p,  P38703,  P38703p,  YHL003C ...

Linkouts:  STRING  UniProt