Cyclebase 3.0

Cell-cycle regulation database

CDC14 [YFR028C]

Tyrosine-protein phosphatase CDC14; Protein phosphatase required for mitotic exit; required for rDNA segregation, cytokinesis, meiosis I spindle disassembly, environmental stress response; held in nucleolus by Cdc55p in early meiosis, liberated by FEAR and Mitotic Exit Network in anaphase, enabling it to effect a decrease in CDK/B-cyclin activity and mitotic exit; sequestered in metaphase II, released upon entry into anaphase II; human homolog CDC14A can complement thermosensitivity of yeast cdc14-1 mutant

Synonyms:  CDC14,  CDC14p,  Q00684,  OAF3,  Q00684p ...

Linkouts:  STRING  UniProt