Cyclebase 3.0

Cell-cycle regulation database

SCC2 [YDR180W]

Sister chromatid cohesion protein 2; Subunit of cohesin loading factor (Scc2p-Scc4p); a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; promotes gene expression program that supports translational fidelity; evolutionarily-conserved adherin; relocalizes to cytosol in response to hypoxia; human disorder Cornelia de Lange syndrome is caused by mutations in NIPBL, the human ortholog of SCC2

Synonyms:  SCC2,  SCC2p,  Q04002,  Q04002p,  YD9395.14 ...

Linkouts:  STRING  UniProt