Cyclebase 3.0

Cell-cycle regulation database

TRM82 [YDR165W]

Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound to Trm82p; relocalizes to the cytosol in response to hypoxia; mutation in human ortholog WDR4 causes microcephalic primordial dwarfism

Synonyms:  TRM82,  TRM82p,  Q03774,  Q03774p,  YD8358.19 ...

Linkouts:  STRING  UniProt