Cyclebase 3.0

Cell-cycle regulation database

SAC6 [YDR129C]

Fimbrin, actin-bundling protein; cooperates with Scp1p in organization and maintenance of the actin cytoskeleton; phosphorylated by Cdc28p/Clb2p in metaphase on T103, to regulate conformation, and modulate actin filament binding affinity and actin cable dynamics; relocalizes from the plasma membrane to the cytoplasm upon DNA replication stress; human homologs PLS3 and LCP1 implicated in spinocerebellar ataxia type 2 (SCA2) can each complement yeast null mutant

Synonyms:  SAC6,  SAC6p,  P32599,  P32599p,  YD9302.04C ...

Linkouts:  STRING  UniProt