Cyclebase 3.0

Cell-cycle regulation database

STE5 [YDR103W]

Protein STE5; Pheromone-responsive MAPK scaffold protein; couples activation of the G-protein-coupled pheromone receptor to MAPK activation; intramolecular interaction of PH and VWA domains blocks activation of assembled signaling cascade components (Ste11p, Ste7p and Fus3p) under basal conditions; Gbeta-gamma (Ste4p-Ste18p)-dependent docking at the plasma membrane and binding of PI(4,5)P2 by the PH domain relieves autoinhibition, resulting in pheromone-dependent pathway activation

Synonyms:  STE5,  STE5p,  P32917,  NUL3,  P32917p ...

Linkouts:  STRING  UniProt