RIO1 [YOR119C]
Serine/threonine-protein kinase RIO1; Serine kinase involved in cell cycle regulation and rDNA integrity; associated with late pre-40S particles via its conserved C-terminal domain and participates in late 40S biogenesis; association with pre-40S particles regulated by its catalytic ATPase site and likely occurs after the release of Rio2p from these particles; involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA; phosphorylates Rpa43p in anaphase to remove Pol I from rDNA; Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.
Synonyms: RIO1, RIO1p, Q12196, O3266, Q12196p ...