Cyclebase 3.0

Cell-cycle regulation database

TOF1 [YNL273W]

Topoisomerase 1-associated factor 1; Subunit of a replication-pausing checkpoint complex; Tof1p-Mrc1p-Csm3p acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase; relocalizes to the cytosol in response to hypoxia

Synonyms:  TOF1,  TOF1p,  P53840,  N0636,  P53840p ...

Linkouts:  STRING  UniProt