RKR1 [YMR247C]
RING domain mutant killed by rtf1 deletion protein 1; RING domain E3 ubiquitin ligase; involved in ubiquitin-mediated degradation of non-stop proteins and translationally stalled ER membrane proteins; component of ribosome-bound RQC (ribosome quality control) complex; degrades products of mRNAs lacking a termination codon regardless of a poly(A) tail; functional connections to chromatin modification; homolog of mouse Listerin, mutations in which reported to cause neurodegeneration; Belongs to the LTN1 family.
Synonyms: RKR1, RKR1p, Q04781, LTN1, Q04781p ...