Cyclebase 3.0

Cell-cycle regulation database

TSA1 [YML028W]

Thioredoxin-dependent peroxide reductase; Thioredoxin peroxidase; acts as both ribosome-associated and free cytoplasmic antioxidant; self-associates to form high-molecular weight chaperone complex under oxidative stress; chaperone activity essential for growth in zinc deficiency; required for telomere length maintenance; binds and modulates Cdc19p activity; protein abundance increases, forms cytoplasmic foci during DNA replication stress; TSA1 has a paralog, TSA2, that arose from the whole genome duplication; Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.

Synonyms:  TSA1,  TSA1p,  P34760,  P34760p,  TPX1 ...

Linkouts:  STRING  UniProt