COF1 [YLL050C]
Actin-depolymerizing factor 1; Cofilin, involved in pH-dependent actin filament depolarization; binds both actin monomers and filaments and severs filaments; involved in the selective sorting, export of the secretory cargo from the late golgi; genetically interacts with pmr1; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes; Belongs to the actin-binding proteins ADF family.
Synonyms: COF1, COF1p, Q03048, L0596, Q03048p ...