Cyclebase 3.0

Cell-cycle regulation database

BUB1 [YGR188C]

Protein kinase involved in the cell cycle checkpoint into anaphase; in complex with Mad1p and Bub3p, prevents progression into anaphase in presence of spindle damage; Cdc28p-mediated phosphorylation at Bub1p-T566 is important for degradation in anaphase and adaptation of checkpoint to prolonged mitotic arrest; associates with centromere DNA via Skp1p; involved in Sgo1p relocalization in response to sister kinetochore tension; paralog MAD3 arose from whole genome duplication

Synonyms:  BUB1,  BUB1p,  P41695,  G7542,  P41695p ...

Linkouts:  STRING  UniProt