BRR6 [YGL247W]
Bad response to refrigeration protein 6; Essential nuclear envelope integral membrane protein; interacts and functions with Apq12p and Brl1p in lipid homeostasis; mutants are defective in nuclear pore complex biogenesis, nuclear envelope morphology, mRNA nuclear export, and are sensitive to sterol biosynthesis inhibitors and membrane fluidizing agents; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism; homologous to Brl1p; Belongs to the BRL1/BRR6 family.
Synonyms: BRR6, BRR6p, P53062, NRA197, P53062p ...