Cyclebase 3.0

Cell-cycle regulation database

ALG2 [YGL065C]

GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase; Mannosyltransferase in the N-linked glycosylation pathway; catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol; human ALG2 complements the temperature sensitivity and dolichol-linked oligosaccharide biosynthesis defect of the alg2-1 mutant, but mutant form from a patient with CDG-Ii fails to complement; Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.

Synonyms:  ALG2,  ALG2p,  P43636,  P43636p,  YGL065C ...

Linkouts:  STRING  UniProt