Cyclebase 3.0

Cell-cycle regulation database

GIS1 [YDR096W]

Transcriptional activator/repressor GIS1; Histone demethylase and transcription factor; regulates genes during nutrient limitation; activity modulated by proteasome-mediated proteolysis; has JmjC and JmjN domain in N-terminus that interact, promoting stability and proper transcriptional activity; contains two transactivating domains downstream of Jmj domains and a C-terminal DNA binding domain; relocalizes to the cytosol in response to hypoxia; GIS1 has a paralog, RPH1, that arose from the whole genome duplication

Synonyms:  GIS1,  GIS1p,  Q03833,  Q03833p,  YD8557.01 ...

Linkouts:  STRING  UniProt