CDC7 [YDL017W]
Cell division control protein 7; DDK (Dbf4-dependent kinase) catalytic subunit; required for origin firing and replication fork progression in mitotic S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression; required for pre-meiotic DNA replication, meiotic DSB formation, recruitment of monopolin complex to kinetochores during meiosis I, regulation of meiosis-specific Ndt80p; mutation complemented by human CDC7 and DBF4 co-expression; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.
Synonyms: CDC7, CDC7p, P06243, D2855, OAF2 ...