CCZ1 [YBR131W]
Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway; Subunit of a heterodimeric guanine nucleotide exchange factor (GEF); subunit of the Mon1-Ccz1 GEF complex, which stimulates nucleotide exchange and activation of Ypt7p, a Rab family GTPase involved in membrane tethering and fusion events at the late endosome and vacuole; GEF activity is stimulated by membrane association and anionic phospholipids; involved in localizing Ypt7p to the vacuolar membrane; required for macroautophagy, the CVT pathway and mitophagy
Synonyms: CCZ1, CCZ1p, P38273, AUT11, CVT16 ...