Cyclebase 3.0

Cell-cycle regulation database

Ctp1 [SPCC338.08.1]

Sporulation in the absence of SPO11 protein 2 homolog; Endonuclease that cooperates with the MRN complex in processing meiotic and mitotic double-strand breaks by allowing the endonucleolytic removal of rec12 from the break sites and ensuring both resection and intrachromosomal association of the broken ends. Required for the formation of RPA-coated single strand DNA adjacent to the DSBs where it functions together with the MRN complex in 5'- 3' resection. Required for the repair of programmed meiotic DSBs. Involved also in an rhp51 recombinase- dependent recombinational repair pathway; Belongs to the COM1/SAE2/CtIP family.

Synonyms:  ctp1,  COM1_SCHPO; COM1_SCHPO; COM1_SCHPO; COM1_SCHPO; COM1_SCHPO,  ctp1p,  mug38,  nip1 ...

Linkouts:  STRING