Cyclebase 3.0

Cell-cycle regulation database

Rik1 [SPCC11E10.08.1]

Chromatin modification-related protein rik1; Component of the rik1-associated E3 ubiquitin ligase complex that shows ubiquitin ligase activity and is required for histone H3K9 methylation. H3K9me represents a specific tag for epigenetic transcriptional repression by recruiting swi6/HP1 to methylated histones which leads to transcriptional silencing within centromeric heterochromatin, telomeric regions and at the silent mating-type loci. Rik1 has also a function in meiotic telomere clustering.

Synonyms:  rik1,  rik1p,  RIK1_SCHPO; RIK1_SCHPO,  SPCC11E10.08,  16040243 ...

Linkouts:  STRING