Crb2 [SPBC342.05.1]
DNA repair protein Rad9 homolog, Rhp9; Essential for cell cycle arrest at the G1 and G2 stages following DNA damage by X-, and UV-irradiation, or inactivation of DNA ligase. Plays a role in the response to DNA damage. Interaction with rad4 via its phosphorylation sites in the N-terminus couples the DNA checkpoint apparatus to chromatin via interaction of its C-terminal BRCT domains with epigenetic modifications on histones H4 and H2A, respectively, in the G1/S phase of the cell cycle, and facilitates recruitment of the checkpoint kinase chk1.
Synonyms: crb2, crb2p, RHP9_SCHPO; RHP9_SCHPO; RHP9_SCHPO, rhp9, SPBC342.05 ...
Linkouts: STRING