Sfc3 [SPBC336.07.1]
Transcription factor TFIIIC complex B box binding subunit Sfc3; TFIIIC mediates tRNA and 5S RNA gene activation by binding to intragenic promoter elements. Upstream of the transcription start site, TFIIIC assembles the initiation complex TFIIIB-TFIIIC-tDNA, which is sufficient for RNA polymerase III recruitment and function. Part of the tauB domain of TFIIIC that binds boxB DNA promoter sites of tRNA and similar genes. Cooperates with sfc6 in DNA binding. Localizes to chromatin insulator sequence without recruiting RNA polymerase III and plays a role in nuclear organization.
Synonyms: sfc3, sfc3p, SFC3_SCHPO; SFC3_SCHPO; SFC3_SCHPO, SPBC336.07, tfc3 ...
Linkouts: STRING