Lsk1 [SPAC2F3.15.1]
P-TEFb-associated cyclin-dependent protein kinase Lsk1; Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity). Together with ctk2/lsc1, required for the regulation of cytokinesis by phosphorylating 'Ser-2' residues found in the heptad repeats of the CTD. Required for nuclear localization of ctk2/lsc1. Positively regulates the septation initiation network (SIN) and promotes successful completion of cytokinesis in response to perturbation of the actomyosin ring. Acts in parallel to clp1 to promote actomyosin ring stability upon cytokinesis checkpoint activation.
Synonyms: lsk1, CTK1_SCHPO; CTK1_SCHPO; CTK1_SCHPO, lsk1p, ctk1, SPAC2F3.15 ...
Linkouts: STRING