Tim8 [SPAC13G6.04.1]
TIM22 inner membrane protein import complex subunit Tim8 (predicted); Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).
Synonyms: tim8, tim8p, TIM8_SCHPO; TIM8_SCHPO, SPAC13G6.04, 2542819 ...
Linkouts: STRING