Cyclebase 3.0

Cell-cycle regulation database

DSN1 [YIR010W]

Kinetochore-associated protein DSN1; Essential component of the MIND kinetochore complex; joins kinetochore subunits contacting DNA to those contacting microtubules; Dsn1p phosphorylation promotes interaction between outer and inner kinetochore proteins; kinetochore receptor for monopolin, via interaction with subunit Csm1p; essential for meiotic but not mitotic chromosome segregation; MIND complex consists of Mtw1p, Nnf1p, Nsl1p and Dsn1p; modified by sumoylation; phosphorylated by monopolin subunit Hrr25p

Synonyms:  DSN1,  DSN1p,  P40568,  P40568p,  YIB10W ...

Linkouts:  STRING  UniProt