ALK2 [YBL009W]
Serine/threonine-protein kinase Haspin homolog ALK2; Protein kinase; along with its paralog, ALK1, required for proper spindle positioning and nuclear segregation following mitotic arrest, proper organization of cell polarity factors in mitosis, proper localization of formins and polarity factors, and survival in cells that activate spindle assembly checkpoint; phosphorylated in response to DNA damage; ALK2 has a paralog, ALK1, that arose from the whole genome duplication; similar to mammalian haspins
Synonyms: ALK2, ALK2p, P32789, P32789p, YBL009W ...
Name | Source | Evidence |
---|---|---|
Cdc28 substrate | Loog et al 2005 | High-throughput |
CDK substrate | Regex | [ST]P.[RK] |
Name | Organism | Rank | Peaktime | Phenotypes | Homology |
---|---|---|---|---|---|
ALK1 | Saccharomyces cerevisiae gene | 61 | G2 | Paralog | |
Hrk1 | Schizosaccharomyces pombe gene | 4901 | non-periodic | Ortholog | |
Haspin | Arabidopsis thaliana gene | 6249 | non-periodic | Ortholog |