NTG1 [YAL015C]
Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase 1; DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; required for maintaining mitochondrial genome integrity; NTG1 has a paralog, NTG2, that arose from the whole genome duplication; Belongs to the Nth/MutY family.
Synonyms: NTG1, NTG1p, P31378, FUN33, OGG2 ...